Oral Immunization against the Pneumococcus

The Rôle of the Soluble Specific Substance in Oral Immunization against Pneumococcus Types Ii and Iii

1. When the soluble specific substance of Type II pneumococcus was fed to rats, little or no increased resistance to the organism was obtained. 2. When the specific substance of Type III pneumococcus was fed, an increased resistance to the virulent organism resulted. The percentage of animals protected is smaller than when the whole or the dissolved cell is fed. 3. When the specific polysacchar...

Oral Immunization against Pneumococcus Types Ii and Iii and the Normal Variation in Resistance to These Types among Rats

1. Considerable variation in the resistance of different rats toward Type II pneumococcus has been demonstrated. In general, older rats survive much greater doses than young ones, illustrating the acquisition of a natural partial immunity. The same is true for Type III but the immunity appears somewhat later in life and does not reach the same height. 2. An active immunity can be created agains...

Stimulating Role of Toxoids-Laden Liposomes in Oral Immunization against Diphteria and Tetanus Infections

Oral Immunization against Diphtheria and Tetanus Infections by Fluid Dphtheria and Tetanus Toxoids

Studies on Immunity to Pneumococcus Mucosus (type Iii)

1. Immunization of rabbits with Type III pneumococci is effective in producing active immunity against infection with a virulent strain of the homologous organism. 2. Immunization of rabbits with Type I or II pneumococci, and with R forms derived from any of the fixed types, is equally effective in producing active immunity against Type III infection. 3. Immunization of rabbits with nucleoprote...

Resistance to Pneumococcus Infection in Rabbits following Immunizing Injections of Heat-killed Pneumococcus Suspensions

The degree and duration of the active resistance against pneumococcus infection have been determined in rabbits which received intravenous injections of a heat-killed suspension of pneumococci of the three principal types. The resistance induced by the immunization procedure varied in degree and in duration with each type of Pneumococcus.